Biography
Videos
Awards & Honors
Award | Conferred By | Date |
---|---|---|
Medal of Excellence - Breakthrough Innovations | American Association of Kidney Patients | 2022 |
Presidential Volunteer Service Award - Gold Medal | U.S. Presidential Volunteer Service awards - nomination by American Association of Kidney Patients | 2022 |
Commendation for Exceptional Volunteerism and University Service | Organized, Rapid, Intelligent Fabrication (ORIF) Team for UCSF's COVD-19 Pandemic Response | 2021 |
KidneyX Artificial Kidney Phase 1, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2021 |
KidneyX Redesign Dialysis Phase 2, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2020 |
Dean's Apple Award - Outstanding Efforts and Commitment to Pharmacy Education | UCSF PharmD Degree Program | 2019 |
KidneyX Redesign Dialysis Phase 1, Winner | US Dept. of Health and Human Services & American Society of Nephrology | 2019 |
Elected Fellow of American Institute of Medical and Biological Engineering (AIMBE) | American Institute of Medical and Biological Engineering (AIMBE) | 2017 |
La Renon TANKER foundation For the Sake of Honour Award | Tamilnad Kidney Research Foundation (TANKER) | 2017 |
Annual Home Dialyzors United (HDU) Chris Blagg Award | Home Dialyzors United (HDU) | 2016 |
Innovation in Regulatory Science, Finalist | Burroughs Wellcome Fund | 2015 |
UCSF Outstanding Faculty Mentorship Award, Finalist | UCSF | 2014 |
Fellow | Applied Innovation Institute | 2013 |
Requested Nominator | Heinz Awards | 2013 |
Rising Star Award | BayBio Pantheon | 2012 |
Innovation Pathway 2.0 Award | Food and Drug Administration (FDA) | 2012 |
UCSF Outstanding Faculty Mentorship Award, Finalist | University of California, San Francisco | 2012 |
mHealth Alliance Award | Vodafone Americas Foundation | 2011 |
Images of the Year Selection | Biomaterials Journal | 2009 |
Biotech Humanitarian Award Finalist | Biotechnology Industry Organization | 2009 |
Thomas G. Orr Memorial Lectureship | Southwestern Surgical Congress | 2008 |
Cleveland Clinic Innovator Award | Cleveland Clinic | 2007 |
Mentor Recognition Award | Cleveland Clinic Science Internship Program | 2006 |
Cleveland Clinic Innovator Award | Cleveland Clinic | 2005 |
Who's Who in Biotechnology | Crain's Cleveland Business | 2005 |
Ribbon Award, Outstanding Symposium Paper, MRS Fall Meeting | Materials Research Society | 2004 |
NASA Group Achievement Award, Harsh Environment MEMS | NASA | 2004 |
MIT TR100 Award, Top 100 Young Innovators | Technology Review Magazine | 2003 |
Clinical Translation Award | BioMEMS and Biomedical Nanotechnology World Meeting | 2001 |
Top 40 Under 40 | Crain's Cleveland Business | 1999 |
Ruth Barber Moon Graduate Student Award | Case Western Reserve University | 1998 |
Senior Physics Prize | Mount Union College | 1992 |
William and Burdella Carl Mathematics Award | Mount Union College | 1989 |
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Case Western Reserve University | PhD | Electrical Engineering and Computer Science | 2001 |
Case Western Reserve University | MS | Electrical Engineering and Applied Physics | 1995 |
Mount Union College | BS | Physics, Mathematics, Computer Science | 1992 |
Clinical Trials
- Blood Flow Effects on Silicon Substrates (NCT03241667)Related Conditions: End Stage Renal Disease| Start Date: | End Date:
Program Affiliations
UCSF - UC Berkeley Joint Graduate Group in Bioengineering
Pharmaceutical Sciences and Pharmacogenomics Graduate Program (PSPG)
UC Berkeley - UCSF Master of Translational Medicine (MTM) Program California Institute for Quantitative Biosciences (QB3)
In the News
Grants and Funding
- Biodevice Innovation Training Program | NIH | 2017-05-15 - 2022-04-30 | Role: Co-Principal Investigator
- Implantable Bio-Artificial Pancreas (iBAP) | NIH | 2017-09-26 - 2021-06-30 | Role: Principal Investigator
- Building an Implantable Artificial Kidney | NIH | 2015-09-30 - 2021-06-30 | Role: Principal Investigator
- Biocompatibility of Implantable Renal Replacement Devices | NIH | 2012-05-01 - 2017-04-30 | Role: Principal Investigator
- Miniaturized Implantable Renal Assist Device for Total Renal Replacement Therapy | NIH | 2007-09-30 - 2011-08-31 | Role: Principal Investigator
- Microneedle Array for Catheter Drug Delivery | NIH | 2003-09-12 - 2006-08-31 | Role: Principal Investigator
Research Narrative
Chronic kidney failure threatens about half a million people in the U.S. alone. Donated kidneys can restore health, but they are in are in short supply. As a result, some 350,000 people with failing kidneys are tethered to dialysis machines several days a week – a tiring, uncomfortable and expensive treatment, and one that falls far short of performing a normal kidney’s functions. Shuvo Roy, a professor in the UCSF Department of Bioengineering and Therapeutic Sciences, and his colleagues are developing an implantable, fully functional artificial kidney.
Research projects include:
- Development of an artificial kidney
- Development of an intravascular bioreactor for islet therapy in Type 1 diabetes patients
- Investigation into covalent attachment of self-assembled monolayer films to enhance biocompatibility of implanted devices
- Resorbable electronics for tissue monitoring and stimulation, and dataloggers for patient monitoring
- Development of compact hemofilters for renal replacement therapy
- Wireless sensing systems for load measurement
- Focused ultrasound transducers for minimally invasive imaging and therapy
Research Interests
Therapeutics
Bioengineering
Medical Devices
Microelectromechanical Systems
BioMEMS
Sensors
Transducers
Biocompatibility
Artificial Organs
Microtextured Substrates
Renal Replacement
Tissue Engineering
Nanotechnology
Artificial Kidney
Publications
- An arteriovenous mock circulatory loop and accompanying bond graph model for in vitro study of peripheral intravascular bioartificial organs.| | View in PubMed
- Patient Preference Trade-offs for Next-Generation Kidney Replacement Therapies.| | View in PubMed
- Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers.| | View in PubMed
- Feasibility of an implantable bioreactor for renal cell therapy using silicon nanopore membranes.| | View in PubMed
- Characterization of human islet function in a convection-driven intravascular bioartificial pancreas.| | View in PubMed
- Silicon membranes for extracorporeal life support: a comparison of design and fabrication methodologies.| | View in PubMed
- Inhibition of Transforming Growth Factor-β Improves Primary Renal Tubule Cell Differentiation in Long-Term Culture.| | View in PubMed
- Functionalizing Polyacrylamide Hydrogels for Renal Cell Culture Under Fluid Shear Stress.| | View in PubMed
- Wearable and implantable artificial kidney devices for end-stage kidney disease treatment: Current status and review.| | View in PubMed
- The Advancing American Kidney Health Initiative: The Challenge of Overcoming the Status Quo.| | View in PubMed
- Superporous agarose scaffolds for encapsulation of adult human islets and human stem-cell-derived β cells for intravascular bioartificial pancreas applications.| | View in PubMed
- Opportunities for Regulatory Changes to Promote Pediatric Device Innovation in the United States: Joint Recommendations From Pediatric Innovator Roundtables.| | View in PubMed
- Use of Ballistocardiography to Monitor Cardiovascular Hemodynamics in Preeclampsia.| | View in PubMed
- Advances in extracorporeal membrane oxygenator design for artificial placenta technology.| | View in PubMed
- Metformin and Inhibition of Transforming Growth Factor-Beta Stimulate In Vitro Transport in Primary Renal Tubule Cells.| | View in PubMed
- Treating the kidneys - a new era in the United States (and beyond).| | View in PubMed
- Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment.| | View in PubMed
- Endovascular Ion Exchange Chemofiltration Device Reduces Off-Target Doxorubicin Exposure in a Hepatic Intra-arterial Chemotherapy Model.| | View in PubMed
- Genome Engineering Renal Epithelial Cells for Enhanced Volume Transport Function.| | View in PubMed
- Ultrafiltration for management of fluid overload in patients with heart failure.| | View in PubMed
- Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.| | View in PubMed
- In Vitro models for thrombogenicity testing of blood-recirculating medical devices.| | View in PubMed
- Application of physiological shear stress to renal tubular epithelial cells.| | View in PubMed
- Compliance monitoring via a Bluetooth-enabled retainer: A prospective clinical pilot study.| | View in PubMed
- Apical Shear Stress Enhanced Organic Cation Transport in Human OCT2/MATE1-Transfected Madin-Darby Canine Kidney Cells Involves Ciliary Sensing.| | View in PubMed
- In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.| | View in PubMed
- Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells.| | View in PubMed
- Acoustic Methods for Pulmonary Diagnosis.| | View in PubMed
- Evaluation of silicon membranes for extracorporeal membrane oxygenation (ECMO).| | View in PubMed
- Innovations in Wearable and Implantable Artificial Kidneys.| | View in PubMed
- Improved Detection of Lung Fluid With Standardized Acoustic Stimulation of the Chest.| | View in PubMed
- Tabla: A Proof-of-Concept Auscultatory Percussion Device for Low-Cost Pneumonia Detection.| | View in PubMed
- Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges.| | View in PubMed
- Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.| | View in PubMed
- Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.| | View in PubMed
- Novel Wearable Seismocardiography and Machine Learning Algorithms Can Assess Clinical Status of Heart Failure Patients.| | View in PubMed
- Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration.| | View in PubMed
- Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.| | View in PubMed
- Silicon Micropore-Based Parallel Plate Membrane Oxygenator.| | View in PubMed
- Correction: An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | View in PubMed
- An intravascular bioartificial pancreas device (iBAP) with silicon nanopore membranes (SNM) for islet encapsulation under convective mass transport.| | View in PubMed
- A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll.| | View in PubMed
- Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models.| | View in PubMed
- Glucose-Stimulated Insulin Response of Silicon Nanopore-Immunoprotected Islets under Convective Transport.| | View in PubMed
- Evolution of Gas Permeable Membranes for Extracorporeal Membrane Oxygenation.| | View in PubMed
- A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.| | View in PubMed
- Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health.| | View in PubMed
- Inductive passive sensor for intraparenchymal and intraventricular monitoring of intracranial pressure.| | View in PubMed
- Diffusive Silicon Nanopore Membranes for Hemodialysis Applications.| | View in PubMed
- First Implantation of Silicon Nanopore Membrane Hemofilters.| | View in PubMed
- Silicon nanopore membrane (SNM) for islet encapsulation and immunoisolation under convective transport.| | View in PubMed
- Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.| | View in PubMed
- Progress and challenges in macroencapsulation approaches for type 1 diabetes (T1D) treatment: Cells, biomaterials, and devices.| | View in PubMed
- MyPectus: First-in-human pilot study of remote compliance monitoring of teens using dynamic compression bracing to correct pectus carinatum.| | View in PubMed
- Corrigendum to: Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.| | View in PubMed
- A Wearable Patch to Enable Long-Term Monitoring of Environmental, Activity and Hemodynamics Variables.| | View in PubMed
- Impedance sensing device enables early detection of pressure ulcers in vivo.| | View in PubMed
- The synergistic effect of micro-topography and biochemical culture environment to promote angiogenesis and osteogenic differentiation of human mesenchymal stem cells.| | View in PubMed
- Biocompatibility evaluation of a thermoplastic rubber for wireless telemetric intracranial pressure sensor coating.| | View in PubMed
- Current strategies and challenges in engineering a bioartificial kidney.| | View in PubMed
- Impedance sensing device for monitoring ulcer healing in human patients.| | View in PubMed
- Toward continuous, noninvasive assessment of ventricular function and hemodynamics: wearable ballistocardiography.| | View in PubMed
- Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding.| | View in PubMed
- Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance.| | View in PubMed
- Miniaturizing RFID for magnamosis.| | View in PubMed
- Tracking clinical status for heart failure patients using ballistocardiography and electrocardiography signal features.| | View in PubMed
- Wearable ballistocardiography: preliminary methods for mapping surface vibration measurements to whole body forces.| | View in PubMed
- Microelectromechanical systems and nephrology: the next frontier in renal replacement technology.| | View in PubMed
- A low-frequency versatile wireless power transfer technology for biomedical implants.| | View in PubMed
- Towards BirthAlert--A Clinical Device Intended for Early Preterm Birth Detection.| | View in PubMed
- Response of bone marrow derived connective tissue progenitor cell morphology and proliferation on geometrically modulated microtextured substrates.| | View in PubMed
- The bioartificial kidney: current status and future promise.| | View in PubMed
- Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices.| | View in PubMed
- Fabric-based pressure sensor array for decubitus ulcer monitoring.| | View in PubMed
- Novel device to trend impedance and fluorescence of the cervix for preterm birth detection.| | View in PubMed
- Implantable ultra-low pulmonary pressure monitoring system for fetal surgery.| | View in PubMed
- A feed-forward controlled AC-DC boost converter for biomedical implants.| | View in PubMed
- Dynamic tracheal occlusion improves lung morphometrics and function in the fetal lamb model of congenital diaphragmatic hernia.| | View in PubMed
- Hemocompatibility of silicon-based substrates for biomedical implant applications.| | View in PubMed
- Anti-biofouling Sulfobetaine Polymer Thin Films on Silicon and Silicon Nanopore Membranes.| | View in PubMed
- The Responsivity of a Miniaturized Passive Implantable Wireless Pressure Sensor.| | View in PubMed
- A microfluidic bioreactor with integrated transepithelial electrical resistance (TEER) measurement electrodes for evaluation of renal epithelial cells.| | View in PubMed
- Basal lamina secreted by MDCK cells has size- and charge-selective properties.| | View in PubMed
- Design and analysis of MEMS based PVDF ultrasonic transducers for vascular imaging.| | View in PubMed
- Molecular conformation and filtration properties of anionic Ficoll.| | View in PubMed
- Silicon induces minimal thromboinflammatory response during 28-day intravascular implant testing.| | View in PubMed
- Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers.| | View in PubMed
- Characterizing the surface charge of synthetic nanomembranes by the streaming potential method.| | View in PubMed
- Permeability - Selectivity Analysis for Ultrafiltration: Effect of Pore Geometry.| | View in PubMed
- A high-power versatile wireless power transfer for biomedical implants.| | View in PubMed
- The implantable artificial kidney.| | View in PubMed
- Modulating human connective tissue progenitor cell behavior on cellulose acetate scaffolds by surface microtextures.| | View in PubMed
- Solute partitioning and filtration by extracellular matrices.| | View in PubMed
- Post microtextures accelerate cell proliferation and osteogenesis.| | View in PubMed
- A three-dimensional scaffold with precise micro-architecture and surface micro-textures.| | View in PubMed
- Biomolecular transport through hemofiltration membranes.| | View in PubMed
- High-Performance Silicon Nanopore Hemofiltration Membranes.| | View in PubMed
- Development of multistage magnetic deposition microscopy.| | View in PubMed
- Basic Science Symposium II: MEMS Technology.| | View in PubMed
- In Vivo Assessment of Bone Graft/Endplate Contact Pressure in a Caprine Interbody Pseudarthrosis Model: A Preliminary Biomechanical Characterization of the Fusion Process for the Development of a Microelectromechanical Systems (MEMS) Biosensor.| | View in PubMed
- A preliminary biomechanical evaluation in a simulated spinal fusion model. Laboratory investigation.| | View in PubMed
- Quantification of magnetic susceptibility in several strains of Bacillus spores: implications for separation and detection.| | View in PubMed
- Ficoll is not a rigid sphere.| | View in PubMed
- Development of continuous implantable renal replacement: past and future.| | View in PubMed
- Connective tissue progenitor cell growth characteristics on textured substrates.| | View in PubMed
- Differentiated growth of human renal tubule cells on thin-film and nanostructured materials.| | View in PubMed
- Electrochemical detection and characterization of proteins.| | View in PubMed
- Continuous flow magnetic cell fractionation based on antigen expression level.| | View in PubMed
- Orthogonal-coil RF probe for implantable passive sensors.| | View in PubMed
- Evaluation of silicon nanoporous membranes and ECM-based microenvironments on neurosecretory cells.| | View in PubMed
- Spine biomechanics: fundamentals and future.| | View in PubMed
- Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems.| | View in PubMed
- A system for micro/nano fluidic flow diagnostics.| | View in PubMed
- Micromachines in spine surgery.| | View in PubMed
- Osteoblast attachment to a textured surface in the absence of exogenous adhesion proteins.| | View in PubMed
- Growth of connective tissue progenitor cells on microtextured polydimethylsiloxane surfaces.| | View in PubMed
- Analysis of connective tissue progenitor cell behavior on polydimethylsiloxane smooth and channel micro-textures.| | View in PubMed
- Biomaterials and implantable devices: discoveries in the spine surgery arena.| | View in PubMed